Basic Uniphyllin Information

• INN (International Nonproprietary Name): theophylline
• Brand Names Available in United Kingdom: Theo-24®, Elixophyllin®, Theo-Dur®, Afonilum SR, Slo-Phyllin, Theolair
• ATC Code: R03DA04
• Forms & Dosages: Extended-release capsules (100 mg, 200 mg, 300 mg, 400 mg), liquid (oral solution), extended-release tablets
• Manufacturers in United Kingdom: Sanofi, Teva, multiple local and global suppliers
• Registration Status in United Kingdom: Prescription only
• OTC / Rx Classification: Prescription only (Rx)

Everyday Use & Best Practices

When integrating uniphyllin into daily routines, understanding the best timing for dosage is essential. Generally, dosing can be tailored to a patient’s lifestyle and specific symptoms. For instance:

• Morning Dosing: Ideal for individuals experiencing night-time symptoms, helping to maintain improved daytime function.
• Evening Dosing: Suitable when symptoms peak during the night, enabling effective overnight relief.

Regardless of the chosen time, consistency is key. Regular dosing helps maintain stable drug levels in the body, promoting its effectiveness.

Taking With or Without Meals (UK Diet Habits)

Food consumption can significantly affect the absorption of uniphyllin. Here are some simple guidelines:

• Taking the medication on an empty stomach, about an hour before or two hours after meals, can enhance absorption.
• In the context of traditional UK meals, patients may find it beneficial to plan their dose around breakfast or dinner times for consistency.

Avoid high-fat meals before taking uniphyllin, as they may hinder absorption. Understanding local dietary patterns can help ensure optimal medication effectiveness.

Safety Priorities

Prioritising safety when using uniphyllin is paramount. The MHRA outlines specific guidelines for individuals who should avoid this medication. Key contraindications include:

• Known hypersensitivity to theophylline or similar compounds.
• Uncontrolled arrhythmias.
• Severe peptic ulcer disease.

Caution should also be exercised in patients with severe liver disease, congestive heart failure, or seizure disorders. Consulting medical professionals before starting treatment is crucial.

Activities to Limit (Driving, Work Safety)

As uniphyllin may cause side effects such as drowsiness or dizziness, it's advisable to limit high-risk activities, including:

• Driving until individual tolerance is known.
• Operating potentially dangerous machinery or performing tasks requiring full attention.

Monitoring how the body reacts to uniphyllin before engaging in such activities can help prevent accidents.

Dosage & Adjustments

Adhering to the recommended dosage is essential. Standard doses for adults, based on NHS guidelines, typically start at 300-400 mg daily, adjusted according to individual response. Patients must ensure they stick to prescribed schedules to maintain therapeutic levels of the medication.

Special Cases (Elderly, Comorbidities)

Dosage may require adjustments for specific populations. For elderly patients or those with liver or kidney impairments, lower starting doses are usually recommended due to the increased risk of adverse reactions. Regular medical consultations to monitor serum levels are crucial in such cases to avert potential toxicity.

User Testimonials

Many users of uniphyllin in the UK report positive outcomes and improvements in their quality of life. Common themes include enhanced respiratory function and fewer symptoms of chronic bronchitis or asthma over long-term use.

Common Challenges (Patient.info, NHS Forums)

Despite the benefits, patients often report side effects, such as:

• Nausea and vomiting
• Headache and restlessness
• Insomnia

Resources like NHS forums and Patient.info can provide invaluable support and insights, helping patients manage their experiences and connect with others facing similar challenges.

Buying Guide

For those considering uniphyllin, it’s readily available at several well-known pharmacies, including Boots, LloydsPharmacy, and Superdrug. Patients can purchase it both in-store and online, offering flexibility and convenience.

Price Comparison (NHS Prescription Charge vs Private)

Costs for uniphyllin can vary across regions in the UK. Patients with NHS prescriptions may benefit from lower costs and possible exemptions based on specific circumstances. Private prescriptions tend to be pricier; nevertheless, they offer alternatives for those not eligible for NHS coverage.

What’s Inside & How It Works

Ingredients Overview

Uniphyllin's primary active ingredient is theophylline, renowned for its role as a bronchodilator. This compound expands the airways in the lungs, making it easier for individuals suffering from respiratory conditions like asthma or chronic obstructive pulmonary disease (COPD) to breathe.

While theophylline works to alleviate symptoms, Uniphyllin does include some inactive ingredients that may affect sensitivities in certain patients, such as lactose or colourings. These additives can lead to allergic reactions in susceptible individuals, emphasising the need for careful monitoring and consultation with healthcare professionals.

Mechanism Basics Explained Simply

Understanding how Uniphyllin functions can demystify its therapeutic effects. Theophylline exerts its pharmacological action primarily through relaxing the smooth muscles of the respiratory tract. It inhibits specific enzymes responsible for inflammation and promotes airflow.

This double action means not only does Uniphyllin clear airways, but it effectively manages chronic respiratory conditions over the long term, offering consistent relief to individuals who struggle with lung-related ailments.

Main Indications

Approved Uses (MHRA Listing)

Uniphyllin holds approved indications for the management of chronic respiratory conditions, primarily asthma and COPD. Its efficacy is recognised by the Medicines and Healthcare products Regulatory Agency (MHRA). The drug is indicated for patients needing long-term control of their symptoms, especially those who have not responded adequately to other treatments.

In chronic bronchitis and emphysema cases, theophylline aids in increasing blood flow to the lungs, promoting the removal of mucus and reducing breathing difficulty.

Off-label Uses in UK Clinics

Some clinicians may explore off-label uses of Uniphyllin based on individual assessments, particularly in cases where conventional treatments have failed.

Decisions on off-label applications underscore the importance of physician discretion and the careful consideration of potential benefits against any risks that may arise from using Uniphyllin in non-approved scenarios.

Interaction Warnings

Food Interactions (Alcohol, Tea/Coffee)

Patients taking Uniphyllin are advised to consider their diet carefully. Certain foods and beverages can impact the drug's efficacy or safety. For instance, alcohol can exacerbate side effects like dizziness or drowsiness.

Similarly, consuming caffeine-rich beverages such as tea and coffee may heighten the stimulant effects of theophylline, leading to increased heart rate or restlessness. Ideally, these should be avoided during treatment for optimal results.

Drug Conflicts (MHRA Yellow Card Reports)

Known drug interactions with Uniphyllin have been reported through the MHRA Yellow Card scheme, encompassing various medications. Notable drugs to be vigilant about include certain antibiotics and anti-seizure medications that can alter theophylline levels in the blood.

Patients must report any adverse side effects following Uniphyllin intake to the Yellow Card scheme, contributing to ongoing safety assessments and better management of interactions.

Latest Evidence & Insights

Recent studies conducted in the UK and EU from 2022 to 2025 have shed new light on the efficacy and safety of Uniphyllin. Emerging evidence suggests optimal dosing strategies that can significantly affect patient outcomes.

Spanning pivotal research, these insights have demonstrated how tailored administration of theophylline can lead to improved control of asthma and COPD, enhancing quality of life for many patients across the region.

Alternative Choices

While Uniphyllin is a reliable alternative for individuals unresponsive to common therapies, understanding its pros and cons remains essential for effective management of respiratory conditions.

Regulation Snapshot

The current approval status for Uniphyllin (theophylline) in the UK is that it is registered as a prescription-only medication. It is part of the NHS framework for prescribing within respiratory care settings, specifically designed for managing conditions such as asthma and chronic obstructive pulmonary disease (COPD). Healthcare professionals generally recommend Uniphyllin when conventional treatment options are insufficient.

Recent regulatory changes have focused on enhancing the drug’s availability. There have been movements to ensure better access through the NHS, ensuring that healthcare professionals have the necessary guidelines to prescribe it effectively. Moreover, ongoing review processes aim to streamline its use and monitor any emerging safety concerns.

FAQ Section

For patients considering Uniphyllin, several common questions arise. Here’s a selection of practical inquiries with concise answers:

• What is Uniphyllin used for? Uniphyllin is commonly prescribed for asthma and COPD, acting as a bronchodilator to relieve symptoms like wheezing and breathlessness.
• Can Uniphyllin tablets be split or halved? It's typically advised not to halve Uniphyllin tablets as doing so can affect the release mechanism of the medication.
• What are the side effects of Uniphyllin? Some common side effects include nausea, headache, and restlessness. It's vital to report any severe reactions to a healthcare professional.
• Is Uniphyllin a steroid? No, Uniphyllin is not a steroid. It belongs to the class of medications known as xanthines, used to relax airway muscles.

Guidelines for Proper Use

For proper usage of Uniphyllin, pharmacists should provide tailored advice to ensure patients understand their treatment. Key points include:

• **Dosage Instructions:** Always take the medication as directed. Extended-release forms should not be crushed or chewed.
• **Health Monitoring:** Regular monitoring of the patient’s response is essential, including serum theophylline levels, particularly for patients with liver or kidney issues.
• **Medication Compliance:** Emphasize the importance of adhering to the prescribed dosage schedule to maintain effective symptom control.
• **Guidance on Missed Doses:** Patients should be advised on what to do if they miss a dose, usually taking it as soon as remembered unless it’s close to the next scheduled dose.

NHS patient support resources are also available, facilitating ongoing medication management. For individuals experiencing difficulty with their treatment, it's crucial to reach out for professional support, including educational workshops or helplines to improve understanding of their condition and medication.

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